secondary metabolites and biological activities of talaromyces sp. lgt-2, an endophytic fungus from tripterygium wilfordii

abstract in the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from talaromyces sp. lgt-2, an endophytic fungus from tripterygium wilfordi. their structures were determined based on nmr and esi-ms spectral data, as well as comparing with previous literature data. this is the first report of the isolation of alkaloids (1-9) from talaromyces genus. in the next step, all compounds were screened for their anti-monoamine oxidase, anti-acetylcholinesterase, antibacterial and antitumor activities. compound 11 showed moderate anti-monoamine oxidase activity with ic50 value of 61 μm; compounds 3, 4, 8 showed weaker anti-acetylcholinesterase activity; compounds 1, 3, 4, 7, 8, 9 showed moderate antibacterial activities; compounds 7, 8, 9 showed cytotoxicity against b16 cancer cell line with inhibitory rate of 86%, 82%, 78%, respectively, at the concentration of 500 μg/ml.